Cost Comparison of Atypical Antipsychotics: Paliperidone ER and Risperidone
نویسندگان
چکیده
منابع مشابه
Efficacy and tolerability of paliperidone ER and other oral atypical antipsychotics in schizophrenia.
UNLABELLED Atypical antipsychotics are widely used in the pharmacologic management of schizophrenia. Information to guide evidence-based clinical decision making must be continually updated, particularly as new clinical trial data and new antipsychotic agents become available. OBJECTIVE This meta-analysis of oral atypical antipsychotics assessed the relative effectiveness and tolerability pro...
متن کاملThe Pharmacological Role and Clinical Applications of Antipsychotics’ Active Metabolites: Paliperidone versus Risperidone
Some antipsychotic drugs are metabolized in the liver, leading to active metabolites. These metabolites can maintain the effect of the original substrate or display different pharmacokinetic or pharmacodynamic properties, and that can be translated by a different profile of responses and interactions to clinical level. Among these is risperidone, whose active metabolite, 9-OH-risperidone, is kn...
متن کاملPaliperidone palmitate and risperidone long-acting injectable in subjects with schizophrenia recently treated with oral risperidone or other oral antipsychotics
BACKGROUND This post hoc subgroup analysis of a randomized, double-blind trial evaluated the response to treatment with two long-acting injectable atypical antipsychotics, ie, paliperidone palmitate and risperidone long-acting injectable (RLAI), in subjects with schizophrenia experiencing clinically significant symptoms despite recent treatment with oral risperidone only or other oral antipsych...
متن کاملComparative Pharmacology of Risperidone and Paliperidone
Antipsychotics, risperidone, and risperidone's active metabolite, paliperidone (9-hydroxyrisperidone), are related molecules used for the treatment of schizophrenia and related disorders. Differences in receptor binding, 5-HT2A/D2 (serotonin/dopamine) binding ratios, and mitochondrial proteomics suggest that the effects of risperidone and paliperidone on neuronal firing, regulation of mitochond...
متن کاملPaliperidone ER and oral risperidone in patients with schizophrenia: a comparative database analysis
BACKGROUND To compare the efficacy and tolerability of paliperidone extended-release (ER) with risperidone immediate-release using propensity score methodology. METHODS Six double-blind, randomized, placebo-controlled, short-term clinical trials for acute schizophrenia with availability of individual patient-level data were identified (3 per compound). Propensity score pairwise matching was u...
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ژورنال
عنوان ژورنال: Hospital Pharmacy
سال: 2018
ISSN: 0018-5787,1945-1253
DOI: 10.1177/0018578718809269